Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants
and diets. They are believed to have various bioactive effects including anti-viral, anti …

The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily
to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by …

SGLTs are sodium glucose transporters found on the luminal membrane of the proximal
tubule, where they reabsorb some 180 g (1 mol) of glucose from the glomerular filtrate each …

Traditional treatments for type 1 and type 2 diabetes are often associated with side effects,
including weight gain and hypoglycaemia that may offset the benefits of blood glucose …

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is
mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate …

There are three families of glucose transporters in the human genome, SLC2, SLC5 and
SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The human …

Covering: up to March 2013 In addition to their prominent role in basic biological and
chemical research, natural products are a rich source of commercial products for the …

Abstract Sodium-glucose co-transporter 2 (SGLT2) is predominantly expressed in the S1
segment of the proximal tubule of the kidney and is the major transporter responsible for …

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease in the
United States and the world alike, and there is a great unmet need for treatments to reduce …

Abstract Na+-glucose cotransporter 1 (SGLT1)-mediated glucose uptake leads to activation
of Na+-H+ exchanger 3 (NHE3) in the intestine by a process that is not dependent on …