To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …

The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear,. Here we analysed temporally separated DNA-sequencing …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Metastases are responsible for the majority of cancer-related deaths. Although genomic
heterogeneity within primary tumors is associated with relapse, heterogeneity among …