Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Spatiotemporal control of biology: Synthetic photochemistry toolbox with far-red and near-infrared light

S Jia, EM Sletten - ACS chemical biology, 2021 - ACS Publications
The complex network of naturally occurring biological pathways motivates the development
of new synthetic molecules to perturb and/or detect these processes for fundamental …

Near infrared light-triggered nanoparticles using singlet oxygen photocleavage for drug delivery systems

CG Dariva, JFJ Coelho, AC Serra - Journal of Controlled Release, 2019 - Elsevier
Drug delivery systems (DDSs) have showed a reduced systemic toxicity and enhanced
therapeutic efficacy over conventional cancer treatments. However, after reaching the …

Prodrug strategies for targeted therapy triggered by reactive oxygen species

JP Cadahía, V Previtali, NS Troelsen, MH Clausen - MedChemComm, 2019 - pubs.rsc.org
Increased levels of reactive oxygen species (ROS) have been associated with numerous
pathophysiological conditions including cancer and inflammation and the ROS stimulus …

Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of combretastatin A-4 to FR-positive tumor

G Nkepang, M Bio, P Rajaputra, SG Awuah… - Bioconjugate …, 2014 - ACS Publications
We examined the concept of a novel prodrug strategy in which anticancer drug can be
locally released by visible/near IR light, taking advantage of the photodynamic process and …

Toward singlet oxygen delivery at a measured rate: A self-reporting photosensitizer

S Erbas-Cakmak, EU Akkaya - Organic letters, 2014 - ACS Publications
A Bodipy-based energy transfer cassette with a singlet oxygen reactive linker between the
donor and acceptor modules has an interesting emergent property, if the acceptor module is …

Synthesis of Phenol‐Derived cis‐Vinyl Ethers Using Ethynyl Benziodoxolone

T Ura, D Shimbo, M Yudasaka… - Chemistry–An Asian …, 2020 - Wiley Online Library
The stereoselective synthesis of cis‐β‐phenoxyvinyl benziodoxolones (cis‐β‐phenol‐VBXs)
from an ethynyl benziodoxolone‐acetonitrile complex (EBX‐MeCN) and various phenols is …

Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs

BM Lamb, CF Barbas III - Chemical Communications, 2015 - pubs.rsc.org
A routine thioketal protecting group reacts rapidly and selectively with singlet oxygen to
reveal ketone products in good (aryl 1, 3-dithiolane) to excellent (aryl 1, 3-oxathiolane) …

Development of prodrugs for PDT-based combination therapy using a singlet-oxygen-sensitive linker and quantitative systems pharmacology

L Nguyen, M Li, S Woo, Y You - Journal of Clinical Medicine, 2019 - mdpi.com
Photodynamic therapy (PDT) has become an effective treatment for certain types of solid
tumors. The combination of PDT with other therapies has been extensively investigated in …

A fiberoptic (photodynamic therapy type) device with a photosensitizer and singlet oxygen delivery probe tip for ovarian cancer cell killing

D Bartusik, D Aebisher, A Ghogare… - Photochemistry and …, 2013 - Wiley Online Library
A portable “fiber optic‐based sensitizer delivery”(FOSD) device has been developed and
studied. Before there might be success in photodynamic therapy (PDT) and antibacterial …