The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …

Idiosyncratic drug‐induced liver injury (DILI) is a significant adverse effect of antitubercular
therapy with isoniazid (INH). Although the drug has been used for many decades, the …

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and
antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low …

Obesity is an increasingly serious epidemic worldwide characterized by an increase in the
number and size of adipocytes. Adipose tissue maintains the balance between lipid storage …

Adipose tissue is instrumental in maintaining metabolic homeostasis by regulating energy
storage in the form of triglycerides. In the case of over-nutrition, adipocytes favorably …

Cancer stem cells (CSCs) are rare sub-population in tumor mass with self-renewal and
differentiation abilities; CSCs are considered as the main cells which are responsible for …

Background Nrf2 regulates oxidative stress, which is essential for cellular function.
Fundamental initiation of Nrf2 in many malignancies increases prosurvival genes & …

Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in
susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but …

Nuclear factor erythroid 2-related factor 1 (NRF1), a ubiquitously expressed CNC-bZIP
transcription factor, plays a critical role in white adipocyte (WAC) biology, whereas the …

Background: Resistance to chemotherapy is a major obstacle in the treatment of human
hepatocellular carcinoma (HCC). Despite playing an important role in chemoprevention …