The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

La prevalencia de la depresión ha aumentado en las últimas décadas debido al enfoque en
la detección de enfermedades psiquiátricas. El propósito de esta revisión bibliográfica fue …

Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Exposures to adverse environments, both psychosocial and physicochemical, are prevalent
and consequential across a broad range of childhood populations. Such adversity …

Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …

In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …