The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Mitochondria take up Ca2+ through the mitochondrial calcium uniporter complex to regulate
energy production, cytosolic Ca2+ signalling and cell death,. In mammals, the uniporter …

Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

Mitochondrial Ca 2+ uptake depends on the mitochondrial calcium uniporter (MCU)
complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we …

Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …

Mitochondrial Ca 2+ uptake tailors the strength of stimulation of plasma membrane
phospholipase C–coupled receptors to that of cellular bioenergetics. However, how Ca 2+ …

The mitochondrial calcium uniporter is a Ca2+-gated ion channel complex that controls
mitochondrial Ca2+ entry and regulates cell metabolism. MCU and EMRE form the channel …

The mitochondrial calcium uniporter (MCU) is a protein located in the inner mitochondrial
membrane that is responsible for mitochondrial Ca 2+ uptake. Under certain pathological …

Mitochondrial Ca2+ uptake is mediated by an inner mitochondrial membrane protein called
the mitochondrial calcium uniporter. In humans, the uniporter functions as a holocomplex …