Introduction We performed a systematic review and meta-analysis of the Alzheimer's
disease (AD) literature to examine consistency of functional connectivity alterations in AD …

Carcinomas are complex ecosystems composed of cancer, stromal and immune cells.
Communication between these cells and their microenvironments induces cancer …

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Motivation Estimating microbial association networks from high-throughput sequencing data
is a common exploratory data analysis approach aiming at understanding the complex …

Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …

Apicomplexan parasites cause major human disease and food insecurity. They owe their
considerable success to highly specialized cell compartments and structures. These …

Droplet-based single-cell RNA sequencing protocols have dramatically increased the
throughput of single-cell transcriptomics studies. A key computational challenge when …

In this work, we compare the resolution of V2-V3 and V3-V4 16S rRNA regions for the
purposes of estimating microbial community diversity using paired-end Illumina MiSeq …

Gene set enrichment analysis (GSEA) is an ubiquitously used tool for evaluating pathway
enrichment in transcriptional data. Typical experimental design consists in comparing two …

Single-cell RNA sequencing (scRNA-seq) is widely used to profile the transcriptome of
individual cells. This provides biological resolution that cannot be matched by bulk RNA …