[HTML][HTML] Antiviral PROTACs: Opportunity borne with challenge
J Liang, Y Wu, K Lan, C Dong, S Wu, S Li, HB Zhou - Cell Insight, 2023 - Elsevier
Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of
the ubiquitin-proteasome-system has become a promising strategy in drug design. The …
the ubiquitin-proteasome-system has become a promising strategy in drug design. The …
Assessing the potential contribution of in silico studies in discovering drug candidates that interact with various SARS-CoV-2 receptors
AGA Mushebenge, SC Ugbaja, NA Mbatha… - International Journal of …, 2023 - mdpi.com
The COVID-19 pandemic has spurred intense research efforts to identify effective treatments
for SARS-CoV-2. In silico studies have emerged as a powerful tool in the drug discovery …
for SARS-CoV-2. In silico studies have emerged as a powerful tool in the drug discovery …
[HTML][HTML] Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum …
J Desantis, A Bazzacco, M Eleuteri, S Tuci… - European Journal of …, 2024 - Elsevier
Abstract To date, Proteolysis Targeting Chimera (PROTAC) technology has been
successfully applied to mediate proteasomal-induced degradation of several …
successfully applied to mediate proteasomal-induced degradation of several …
Aminoquinolines: fluorescent sensors to DNA–A minor groove probe. Experimental and in silico studies
L de Carvalho Bertozo, M Tutone, B Pastrello… - … of Photochemistry and …, 2023 - Elsevier
An aminoquinoline (AQ4) was developed and proven to be a new and efficient DNA minor
groove fluorescent probe. The specificity for DNA minor groove was attested by comparing it …
groove fluorescent probe. The specificity for DNA minor groove was attested by comparing it …
Comparative analysis of whole-transcriptome RNA expression of lung tissue of Chinese soft-shell turtle infected by Trionyx sinensis Hemorrhagic Syndrome Virus
S Lyu, Q Guo, W Shen, M Han, F Xiong, X Dai… - Fish & Shellfish …, 2024 - Elsevier
Abstract Trionyx sinensis Hemorrhagic Syndrome Virus (TSHSV), the first aquatic arterivirus
identified in China, causes severe mortality to T. sinensis. In this study, we sought to …
identified in China, causes severe mortality to T. sinensis. In this study, we sought to …
Antiviral activity against SARS-CoV-2 variants using in silico and in vitro approaches
HJ Lee, H Choi, A Nowakowska, LW Kang, M Kim… - Journal of …, 2023 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence in 2019 led to
global health crises and the persistent risk of viral mutations. To combat SARS-CoV-2 …
global health crises and the persistent risk of viral mutations. To combat SARS-CoV-2 …
Early Multi-Target Treatment of Mild-to-Moderate COVID-19, Particularly in Terms of Non-Steroidal Anti-Inflammatory Drugs and Indomethacin
S Fazio, P Bellavite - BioMed, 2023 - mdpi.com
Recently, in Italy, a flowchart to be used by General Practitioners for the at-home treatment of
patients with COVID-19, has been released. It states that early at-home treatment for SARS …
patients with COVID-19, has been released. It states that early at-home treatment for SARS …
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
Severe infections with coronaviruses are often accompanied with hyperinflammation,
requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By …
requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By …
In silico identification of chikungunya virus replication inhibitor validated using biochemical and cell‐based approaches
M Chaudhary, A Kumar, K Bala Sharma… - The FEBS …, 2024 - Wiley Online Library
Discovering an alternative therapy with a long‐lasting effect on symptoms caused by
chikungunya virus (CHIKV) infection is prompted by the lack of a vaccine and the absence of …
chikungunya virus (CHIKV) infection is prompted by the lack of a vaccine and the absence of …
Exploring Niclosamide as a Multi-target Drug Against SARS-CoV-2: Molecular Dynamics Simulation Studies on Host and Viral Proteins
P Jagtap, VK Meena, S Sambhare, A Basu… - Molecular …, 2024 - Springer
Niclosamide has emerged as a promising repurposed drug against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). In vitro studies suggested that niclosamide inhibits …
syndrome coronavirus 2 (SARS-CoV-2). In vitro studies suggested that niclosamide inhibits …