Skeletal muscle continuously adapts to changes in its mechanical environment through
modifications in gene expression and protein stability that affect its physiological function …

Complement system activation plays an important role in both innate and acquired immunity.
Activation of the complement and the subsequent formation of C5b-9 channels (the …

Objective Myofiber necrosis without prominent inflammation is a nonspecific finding in
patients with dystrophies and toxic or immune‐mediated myopathies. However, the etiology …

The inflammatory myopathies constitute a heterogeneous group of acquired myopathies that
have in common the presence of endomysial inflammation. Based on steadily evolved …

Background: Recent short-term clinical trials in patients with Duchenne Muscular Dystrophy
(DMD) have indicated greater disease variability in terms of progression than expected. In …

Mutations in dystrophin cause Duchenne muscular dystrophy (DMD), but absent dystrophin
does not invariably cause necrosis in all muscles, life stages and species. Using DNA …

The immune response to acute muscle damage is important for normal repair. However, in
chronic diseases such as many muscular dystrophies, the immune response can amplify …

Facioscapulohumeral muscular dystrophy (FSHD) is a common, dominantly inherited
disease caused by the epigenetic de-repression of the DUX4 gene, a transcription factor …

Over the years various steroid trials have been conducted in Duchenne muscular dystrophy
(DMD). In children who are still able to walk as well as in those who are wheelchair‐bound …

Duchenne muscular dystrophy (DMD) is a lethal X-linked musculodegenerative condition
consisting of an underlying genetic defect whose manifestation is augmented by …