Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele
frequencies shifts at many loci. Current population genomic techniques are not well posed to …

Genetic variation in a population can be summarized through principal component analysis
(PCA) on genome-wide data. PCs derived from such analyses are valuable for genetic …

Type 2 diabetes is more common in non‐Europeans and starts at a younger age and at
lower BMI cut‐offs. This review discusses the insights from genetic studies about …

Disturbed circadian rhythms have been a risk factor for type 2 diabetes mellitus (T2DM).
Melatonin is the major chronobiotic hormone regulating both circadian rhythm and glucose …

Background Prospective cohort studies in relation to the associations between n-3
polyunsaturated fatty acids (PUFA) and risk of type 2 diabetes (T2D) were inconsistent …

Type 2 diabetes is a common disease worldwide, but its prevalence varies widely by
geographical region and by race/ethnicity. This review summarises differences in the …

Candidate gene and genome-wide association studies have not identified common variants,
which are reliably associated with depression. The recent identification of obesity …

Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele
frequencies across worldwide populations. While previous studies have examined …