Caffeine, an antagonist of adenosine A1, A2A and A2B receptors, is known as an adjuvant
analgesic in combination with non-steroidal anti-inflammatory drugs (NSAIDs) and …

Hypnic headache (HH) is a rare primary headache disorder primarily affecting patients over
the age of 50 years. This headache entity occurs exclusively at night almost always at the …

Coffee, tea, and chocolate are among the most frequently consumed products in the world.
The pleasure that many experience from these edibles is accompanied by a range of …

Caffeine and used coffee grounds completely blocked the development of Aedes aegypti in
the early stages, in treatments with the concentrations 1.0 mg/mL and 50 mg/mL …

Annonas are consumed as fresh fruits, but are also widely used in folk medicine for treating
pain and other ailments. Antinociceptive properties of the Annona diversifolia ethanol crude …

The purpose of the present study was to determine whether caffeine modifies the
pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in …

It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal
antiinflammatory drugs (NSAIDs) in several experimental models, however, these effects …

In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA)
and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in …

Drug combinations have been used in clinical practice for the main purpose of increasing
therapeutic effect efficacy. The aim of this study was to determine the antinociceptive effect of …

Abstract Introduction and Objective. The aim of the study was to investigate the effect of bee
venom on the activity of two analgesics: ketoprofen (a non-steroidal anti-inflammatory drug) …