Myelin allows for the rapid and precise timing of action potential propagation along neuronal
circuits and is essential for healthy auditory system function. In this article, we discuss what …

G protein-coupled receptors (GPCRs) are successful druggable targets, making up around
35% of all FDA-approved medications. However, a large number of receptors remain …

Transcription, translation, and turnover of transcripts and proteins are essential for cellular
function. The contribution of those factors to protein levels is under debate, as transcript …

Localization of sound sources is a central aspect of auditory processing. A unique feature of
mammals is the smooth, tonotopically organized extension of the hearing range to high …

Early postnatal brain development involves complex interactions among maturing neurons
and glial cells that drive tissue organization. We previously analyzed gene expression in …

The peripheral deafness gene Mir96 is expressed in both the cochlea and central auditory
circuits. To investigate whether it plays a role in the auditory system beyond the cochlea, we …

Neural tissue maturation is a coordinated process under tight transcriptional control. We
previously analyzed the kinetics of gene expression in the medial nucleus of the trapezoid …

Key points Kv3. 1 and Kv3. 3 subunits are highly expressed in the auditory brainstem, with
little or no mRNA for Kv3. 2 or Kv3. 4. Changes in Kv3 currents and action potential (AP) …

The peripheral and central auditory subsystems together form a complex sensory network
that allows an organism to hear. The genetic programs of the two subsystems must therefore …

Key points Loss of the calcium sensor otoferlin disrupts neurotransmission from inner hair
cells. Central auditory nuclei are functionally denervated in otoferlin knockout mice (Otof …