Rheumatic diseases are characterized by sterile inflammation that causes severe long-term
damage to various organ systems. A growing body of evidence supports a pivotal role for the …

Significance: Macrophages are crucial for tissue homeostasis. Based on their activation,
they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro …

Dysregulation of the balance between pro-inflammatory and anti-inflammatory macrophages
has a key function in the pathogenesis of Duchenne muscular dystrophy (DMD), a fatal …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End
products (RAGE) is critical for skeletal muscle physiology controlling both the activity of …

Primary sarcopenia is a condition of reduced skeletal muscle mass and strength, reduced
agility, and increased fatigability and risk of bone fractures characteristic of aged, otherwise …

The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …

Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

Sarcopenia is common in chronic kidney disease (CKD), and it is independently associated
with morbidity and mortality. Advanced glycation end products (AGE) are mainly known as …