The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …

Lipid metabolism is fundamental to life. In insects, it is critical, during reproduction, flight,
starvation, and diapause. The coordination center for insect lipid metabolism is the fat body …

Triacylglycerol (TAG) is the most important caloric source with respect to energy
homeostasis in animals. In addition to its evolutionarily conserved importance as an energy …

The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid
metabolism is associated with obesity and hyperlipidemia. Although multiple regulatory gut …

The organs and metabolic pathways involved in energy metabolism, and the process of ATP
production from nutrients, are comparable between humans and Drosophila melanogaster …

Drosophila melanogaster represents one of the most important genetically accessible model
organisms for aging research. Studies in flies have identified single gene mutations that …

Being overweight increases the risk of many metabolic disorders, but how it affects lifespan
is not completely clear. Not all obese people become ill, and the exact mechanism that turns …

Studies in mammals, including humans, have reported age-related changes in microbiota
dynamics. A major challenge, however, is to dissect the cause and effect relationships …