The establishing of the first cancer models created a new perspective on the identification
and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft …

Patient‐derived tumour xenografts and tumour organoids have become important preclinical
model systems for cancer research. Both models maintain key features from their parental …

Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Cancers remain a major public health problem worldwide, which still require profound
research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

Patient‐derived xenograft (PDX) models are widely used as preclinical cancer models and
are considered better than cell culture models in recapitulating the histological features …

Despite major progress in elucidating the pathobiology of head and neck squamous cell
carcinoma (HNSCC), the high frequency of disease relapse correlates with unacceptably …

Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively
studied in recent years. Investigating the pathogenesis and potential therapeutic strategies …

The increasing number of available anti-cancer drugs presents a challenge for oncologists,
who must choose the most effective treatment for the patient. Precision cancer medicine …