Therapeutic biology encompasses different modalities, and their manufacturing processes
may be vastly different. However, there are many similarities that run across the different …

Viral vectors are an emerging, exciting class of biologics whose application in vaccines,
oncology, and gene therapy has grown exponentially in recent years. Following first …

The majority of recombinant adeno‐associated viruses (rAAV) approved for clinical use or in
clinical trials areproduced by transient transfection using the HEK293 cell line. However, this …

The use of viral vectors as therapeutic products for multiple applications such as vaccines,
cancer treatment, or gene therapies, has been growing exponentially. Therefore, improved …

The main reasons for performing derivatization in capillary electrophoresis are largely the
same as for liquid chromatography, however there are specific aspects in electrokinetic …

Oncolytic viruses (OV) have emerged as a promising approach to mitigate the challenges of
treating solid cancers. However, the lack of established manufacturing and downstream …

ABSTRACT A holistic understanding of the charge heterogeneity in monoclonal antibodies
(mAbs) is paramount for ensuring acceptable product quality. Hence, biotherapeutic …

In modern medical diagnostics, where analytical chemistry plays a key role, fast and
accurate identification of pathogens is becoming increasingly important. Infectious diseases …

In recent years, there has been an exponential growth in biopharmaceutical development
stemming from its ability to treat previously incurable diseases and to go from pathogen …

Lentivirus vector based on the human immunodeficiency virus-1 (HIV-1) has become a
promising vector for gene transfer studies. The advantageous feature of lentivirus vector is …