Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

Neurodegenerative diseases such as Parkinson's disease (PD) are manifested by inclusion
bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive
decline and dementia onset by intervening before significant neuronal damage occurs. In …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Tauopathies are neurodegenerative diseases that are characterized by accumulation of
hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein …

Aggregation of amyloidogenic proteins is a characteristic of multiple neurodegenerative
diseases. Atomic resolution of small molecule binding to such pathological protein …

Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known
as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The …

A few protein kinases and phosphatases regulate tau protein phosphorylation and an
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …

Despite decades of research, accurate diagnosis of Parkinson's disease remains a
challenge, and disease-modifying treatments are still lacking. Research into the early …