[HTML][HTML] Lipocalin-2: Structure, function, distribution and role in metabolic disorders

S Al Jaberi, A Cohen, C D'Souza… - Biomedicine & …, 2021 - Elsevier
Abstract Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as
neutrophil gelatinase-associated lipocalin (NGAL). LCN-2 is a circulatory protein …

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

JB Funcke, PE Scherer - Journal of lipid research, 2019 - ASBMB
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Lipocalin-2: a master mediator of intestinal and metabolic inflammation

AR Moschen, TE Adolph, RR Gerner, V Wieser… - Trends in Endocrinology …, 2017 - cell.com
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is
released by various cell types and is an attractive biomarker of inflammation, ischemia …

Oxidative stress and low-grade inflammation in polycystic ovary syndrome: controversies and new insights

A Mancini, C Bruno, E Vergani, C d'Abate… - International Journal of …, 2021 - mdpi.com
The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different
mechanisms could contribute to hyperandrogenism and anovulation, which are the main …

The interplay between bone and glucose metabolism

C Cipriani, L Colangelo, R Santori, M Renella… - Frontiers in …, 2020 - frontiersin.org
The multiple endocrine functions of bone other than those related to mineral metabolism,
such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have …

[HTML][HTML] Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

DW Dekens, ULM Eisel, L Gouweleeuw… - Ageing research …, 2021 - Elsevier
Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes

I Mosialou, S Shikhel, N Luo, PI Petropoulou… - Journal of Experimental …, 2020 - rupress.org
Regulation of food intake is a recently identified endocrine function of bone that is mediated
by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat …

[HTML][HTML] Neutrophil gelatinase-associated lipocalin (NGAL) is associated with symptomatic carotid atherosclerosis and drives pro-inflammatory state in vitro

W Eilenberg, S Stojkovic, A Piechota-Polanczyk… - European Journal of …, 2016 - Elsevier
Objective Neutrophil gelatinase-associated lipocalin (NGAL), a protein found in activated
neutrophils, is expressed in kidney tubule cells in response to noxious stimuli, and is thus …

Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing

A Wilhelmsen, K Tsintzas, SW Jones - Geroscience, 2021 - Springer
Sarcopenia, broadly defined as the age-related decline in skeletal muscle mass, quality, and
function, is associated with chronic low-grade inflammation and an increased likelihood of …

Hippocampal lipocalin 2 is associated with neuroinflammation and iron-related oxidative stress in ob/ob mice

Z Jin, KE Kim, HJ Shin, EA Jeong… - … of Neuropathology & …, 2020 - academic.oup.com
Obesity causes brain injuries with inflammatory and structural changes, leading to
neurodegeneration. Although increased circulating lipocalin 2 (LCN2) level has been …