The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
AR Moschen, TE Adolph, RR Gerner, V Wieser… - Trends in Endocrinology …, 2017 - cell.com
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is released by various cell types and is an attractive biomarker of inflammation, ischemia …
The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different mechanisms could contribute to hyperandrogenism and anovulation, which are the main …
C Cipriani, L Colangelo, R Santori, M Renella… - Frontiers in …, 2020 - frontiersin.org
The multiple endocrine functions of bone other than those related to mineral metabolism, such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have …
DW Dekens, ULM Eisel, L Gouweleeuw… - Ageing research …, 2021 - Elsevier
Chronic (neuro) inflammation plays an important role in many age-related central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
I Mosialou, S Shikhel, N Luo, PI Petropoulou… - Journal of Experimental …, 2020 - rupress.org
Regulation of food intake is a recently identified endocrine function of bone that is mediated by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat …
W Eilenberg, S Stojkovic, A Piechota-Polanczyk… - European Journal of …, 2016 - Elsevier
Objective Neutrophil gelatinase-associated lipocalin (NGAL), a protein found in activated neutrophils, is expressed in kidney tubule cells in response to noxious stimuli, and is thus …
A Wilhelmsen, K Tsintzas, SW Jones - Geroscience, 2021 - Springer
Sarcopenia, broadly defined as the age-related decline in skeletal muscle mass, quality, and function, is associated with chronic low-grade inflammation and an increased likelihood of …
Z Jin, KE Kim, HJ Shin, EA Jeong… - … of Neuropathology & …, 2020 - academic.oup.com
Obesity causes brain injuries with inflammatory and structural changes, leading to neurodegeneration. Although increased circulating lipocalin 2 (LCN2) level has been …