Application of computational fluid dynamics in tissue engineering

AR Patrachari, JT Podichetty, SV Madihally - Journal of bioscience and …, 2012 - Elsevier
The process of tissue regeneration consists of a set of complex phenomena such as
hydrodynamics, nutrient transfer, cell growth, and matrix deposition. Traditional cell culture …

Coupling curvature-dependent and shear stress-stimulated neotissue growth in dynamic bioreactor cultures: a 3D computational model of a complete scaffold

Y Guyot, I Papantoniou, FP Luyten, L Geris - Biomechanics and modeling …, 2016 - Springer
The main challenge in tissue engineering consists in understanding and controlling the
growth process of in vitro cultured neotissues toward obtaining functional tissues …

Applications of computational modelling and simulation of porous medium in tissue engineering

CL German, SV Madihally - Computation, 2016 - mdpi.com
In tissue engineering, porous biodegradable scaffolds are used as templates for
regenerating required tissues. With the advances in computational tools, many modeling …

Modeling of porous scaffold deformation induced by medium perfusion

JT Podichetty, SV Madihally - Journal of Biomedical Materials …, 2014 - Wiley Online Library
In this study, we tested the possibility of calculating permeability of porous scaffolds utilized
in soft tissue engineering using pore size and shape. We validated the results using …

Elastohydrodynamics of a deformable porous packing in a channel competing under shear and pressure gradient

P Kumar, GP Sekhar - Physics of Fluids, 2020 - pubs.aip.org
Elastohydrodynamics of a deformable porous medium sandwiched between two parallel
plates is investigated under the influence of an externally applied pressure gradient as well …

A multiscale fluidic device for the study of dendrite-mediated cell to cell communication

S McCutcheon, R Majeska, M Schaffler… - Biomedical …, 2017 - Springer
Many cell types communicate by means of dendritic extensions via a multi-tiered set of
geometric and chemical cues. Until recently, mimicking the compartmentalized in vivo …

Modeling pressure drop using generalized scaffold characteristics in an axial-flow bioreactor for soft tissue regeneration

JT Podichetty, PR Bhaskar, A Khalf… - Annals of biomedical …, 2014 - Springer
The goal of this study was to better understand how analytical permeability models based on
scaffold architecture can facilitate a non-invasive technique to real time monitoring of …

Multiple approaches to predicting oxygen and glucose consumptions by HepG2 cells on porous scaffolds in an axial‐flow bioreactor

JT Podichetty, PR Bhaskar, K Singarapu… - Biotechnology and …, 2015 - Wiley Online Library
In this study, the distribution of oxygen and glucose was evaluated along with consumption
by hepatocytes using three different approaches. The methods include (i) Computational …

Chitosan for cardiac tissue engineering and regeneration

CJ Tormos, SV Madihally - Chitosan Based Biomaterials Volume 2, 2017 - Elsevier
Heart disease is among the top causes of death every year. Current treatment options post-
heart attack are focused on reducing the risk of recurrence, leaving the damaged tissue …

Modeling the impact of fluid flow on resveratrol release from electrospun fibers

T Al-Attar, SV Madihally - Computers in Biology and Medicine, 2020 - Elsevier
Using electrospun fibers to deliver therapeutic agents has gained significant attention in
various applications including cancer treatment and tissue regeneration. However, the effect …