Efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for COVID‐19: a rapid review and meta‐analysis

B Amani, B Amani - Journal of Medical Virology, 2023 - Wiley Online Library
This study aimed to examine the efficacy and safety of nirmatrelvir/ritonavir (Paxlovid) for
coronavirus disease 2019 (COVID‐19). PubMed, Cochrane Library, Web of Science …

Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy

M Ragonnet-Cronin, R Nutalai, J Huo… - Nature …, 2023 - nature.com
COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal
antibodies (mAbs). To minimise virus escape from neutralisation these are administered as …

Therapeutic developments for SARS-CoV-2 infection—molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in …

O Săndulescu, CG Apostolescu… - Frontiers in …, 2023 - frontiersin.org
This article systematically presents the current clinically significant therapeutic
developments for the treatment of COVID-19 by providing an in-depth review of molecular …

Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial

B Maranda, SM Labbé, M Lurquin… - The Lancet Infectious …, 2024 - thelancet.com
Background COVID-19 severity is associated with its respiratory manifestations. Neutralising
antibodies against SARS-CoV-2 administered systemically have shown clinical efficacy …

COVID-19: Management of adults with acute illness in the outpatient setting

P Cohen, K Gebo - UpToDate. UpToDate, 2023 - uptodate.com
At the end of 2019, a novel coronavirus rapidly spread throughout the world, resulting in a
global pandemic. The virus was designated severe acute respiratory syndrome coronavirus …

Clinically Guided Adaptive Machine Learning Update Strategies for Predicting Severe COVID-19 Outcomes

MUS Ayvaci, VS Jacobi, Y Ryu, SPS Gundreddy… - The American Journal of …, 2024 - Elsevier
Background Machine learning algorithms are essential for predicting severe outcomes
during public health crises like COVID-19. However, the dynamic nature of diseases …

[HTML][HTML] Casirivimab-imdevimab treatment is associated with reduced rates of mortality and hospitalization in patients with COVID-19: A systematic review with meta …

M Gao, G Ao, X Hao, B Xie - The Journal of Infection, 2023 - ncbi.nlm.nih.gov
We read with great interest that monoclonal antibody (mAb) cocktail may serve as an
effective and targeted therapeutic strategy in the treatment of patients with COVID-19. 1 …

[HTML][HTML] Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants

J Hwang, S Choi, BK Kim, S Son… - Journal of …, 2025 - pmc.ncbi.nlm.nih.gov
Passive antibody therapies, typically administered via parenteral routes, have played a
crucial role in the initial response to the COVID-19 pandemic. However, the ongoing …

Efficacy and safety of casirivimab and imdevimab for preventing and treating COVID-19: a systematic review and meta-analysis

Z Cui, H Wang, H Zou, L Li, Y Zhang… - Journal of Thoracic …, 2024 - pmc.ncbi.nlm.nih.gov
Background The ongoing global epidemic of coronavirus disease 2019 (COVID-19) has
created a serious public health problem. The selection of safe and effective therapeutic …

Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2

M Ragonnet-Cronin, R Nutalai, J Huo… - bioRxiv, 2022 - biorxiv.org
Some COVID-19 patients are unable to clear their infection or are at risk of severe disease,
requiring treatment with neutralising monoclonal antibodies (nmAb) and/or antivirals. The …