Metallothionein and cadmium toxicology—Historical review and commentary

M Nordberg, GF Nordberg - Biomolecules, 2022 - mdpi.com
More than one and a half centuries ago, adverse human health effects were reported after
use of a cadmium-containing silver polishing agent. Long-term cadmium exposure gives rise …

Chronic kidney disease and exposure to nephrotoxic metals

SE Orr, CC Bridges - International journal of molecular sciences, 2017 - mdpi.com
Chronic kidney disease (CKD) is a common progressive disease that is typically
characterized by the permanent loss of functional nephrons. As injured nephrons become …

Cellular mechanisms of cadmium-induced toxicity: a review

A Rani, A Kumar, A Lal, M Pant - International journal of …, 2014 - Taylor & Francis
Cadmium is a widespread toxic pollutant of occupational and environmental concern
because of its diverse toxic effects: extremely protracted biological half-life (approximately …

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

CKDGen Consortium, KidneyGen Consortium… - Nature, 2011 - nature.com
Blood pressure is a heritable trait influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥ 140 mm …

The blood-testis barrier and its implications for male contraception

CY Cheng, DD Mruk, DR Sibley - Pharmacological reviews, 2012 - Elsevier
The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

The SLC39 family of zinc transporters

J Jeong, DJ Eide - Molecular aspects of medicine, 2013 - Elsevier
Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for
enzymes that are involved in critical biochemical processes and it plays many structural …

Cadmium transport and tolerance in rice: perspectives for reducing grain cadmium accumulation

S Uraguchi, T Fujiwara - Rice, 2012 - Springer
Cadmium (Cd) is a toxic heavy metal which harms human health. In Japan, a major source
of human Cd-intake is rice grains and contamination of paddy soils by Cd and accumulation …

Adverse effects of low level heavy metal exposure on male reproductive function

JJ Wirth, RS Mijal - Systems biology in reproductive medicine, 2010 - Taylor & Francis
Lead, cadmium, mercury, and arsenic, often referred to as “heavy metals”, are toxic for
wildlife, experimental animals, and humans. While experimental animal and human …

Multiple roles of cadmium in cell death and survival

DM Templeton, Y Liu - Chemico-biological interactions, 2010 - Elsevier
Cadmium is a toxic metal with no known biological function. It is increasingly important as an
environmental hazard to both humans and wildlife, and it exemplifies the double edged …

Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals

JM Moulis - Biometals, 2010 - Springer
The widespread occurrence of cadmium in the environment continues to pose a threat to
human health despite attempts at limiting its technological uses. The biologically significant …