Fluorescent probes for targeting the Golgi apparatus: design strategies and applications

S Xu, KC Yan, ZH Xu, Y Wang, TD James - Chemical Society Reviews, 2024 - pubs.rsc.org
The Golgi apparatus is an essential organelle constructed by the stacking of flattened
vesicles, that is widely distributed in eukaryotic cells and is dynamically regulated during cell …

Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Recent advances in chiral carbonized polymer dots: from synthesis and properties to applications

Y Ru, L Ai, T Jia, X Liu, S Lu, Z Tang, B Yang - Nano Today, 2020 - Elsevier
The outstanding properties of carbon dots (CDs), including biocompatibility, low toxicity,
photoluminescence, and easy synthesis and modification, make them strong competitors to …

Structural basis of protein kinase C isoform function

SF Steinberg - Physiological reviews, 2008 - journals.physiology.org
Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

Lipid droplet and peroxisome biogenesis occur at the same ER subdomains

AS Joshi, B Nebenfuehr, V Choudhary… - Nature …, 2018 - nature.com
Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane
but it is not known how sites of biogenesis are determined. We previously identified ER …

Enzymatic assemblies of thiophosphopeptides instantly target Golgi apparatus and selectively kill cancer cells

W Tan, Q Zhang, J Wang, M Yi, H He… - Angewandte Chemie …, 2021 - Wiley Online Library
Changing an oxygen atom of the phosphoester bond in phosphopeptides by a sulfur atom
enables instantly targeting Golgi apparatus (GA) and selectively killing cancer cells by …

Chiral nanoprobes for targeting and long-term imaging of the Golgi apparatus

RS Li, PF Gao, HZ Zhang, LL Zheng, CM Li, J Wang… - Chemical …, 2017 - pubs.rsc.org
The Golgi apparatus is an essential subcellular organelle. Targeting and monitoring the
Golgi change at the single-cell level over a long time scale are critical but are challenges …

Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell

S Modi, C Nizak, S Surana, S Halder… - Nature …, 2013 - nature.com
DNA is a versatile scaffold for molecular sensing in living cells, and various cellular
applications of DNA nanodevices have been demonstrated. However, the simultaneous use …

Architecture of lipid droplets in endoplasmic reticulum is determined by phospholipid intrinsic curvature

V Choudhary, G Golani, AS Joshi, S Cottier… - Current Biology, 2018 - cell.com
Lipid droplets (LDs) store fats and play critical roles in lipid and energy homeostasis. They
form between the leaflets of the endoplasmic reticulum (ER) membrane and consist of a …

Diacylglycerol, when simplicity becomes complex

S Carrasco, I Mérida - Trends in biochemical sciences, 2007 - cell.com
Diacylglycerol (DAG) has unique functions as a basic component of membranes, an
intermediate in lipid metabolism and a key element in lipid-mediated signaling. In …