Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …

TRPV1 is a nonselective cation channel vital for detecting noxious stimuli (heat, acid,
capsaicin). Its role in pain makes it a potential drug target for chronic pain management …

The capsaicin receptor TRPV1 has been intensively studied by cryo-electron microscopy
and functional tests. However, though the apo and capsaicin-bound structural models are …

The selectivity filter (SF) determines which ions are efficiently conducted through ion
channel pores. NaK is a non-selective cation channel that conducts Na+ and K+ with equal …

The nonselective cation channel TRPV1 is responsible for transducing noxious stimuli into
action potentials propagating through peripheral nerves. It is activated by temperatures …

As a member of the transient receptor potential (TRP) channels superfamily, the TRPV1
channel undergoes a closed-to-open gating transition in response to various physical and …

Calcium is the most abundant metal in the human body that plays vital roles as a cellular
electrolyte as well as the smallest and most frequently used signaling molecule. Calcium …

The transient receptor vanilloid 1 (TRPV1) is a non-selective ion channel, which is activated
by several chemical ligands and heat. We have previously shown that activation of TRPV1 …

Molecular dynamics (MD) techniques are widely used in computing free energy changes for
conformational transitions and chemical reactions, mainly in condensed matter systems …

In the last decade two-pore intracellular channels (TPCs) attracted the interest of
researchers, still some key questions remain open. Their importance for vacuolar (plants) …