Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors
Steroid hormone receptors mediate numerous crucial biological processes and are
classically thought to function as transcriptional regulators in the nucleus. However, it has …
classically thought to function as transcriptional regulators in the nucleus. However, it has …
Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease
Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface
The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares
substantial similarity with SARS-CoV. Here, using a computational model of the spike …
substantial similarity with SARS-CoV. Here, using a computational model of the spike …
Supercomputer-based ensemble docking drug discovery pipeline with application to COVID-19
We present a supercomputer-driven pipeline for in silico drug discovery using enhanced
sampling molecular dynamics (MD) and ensemble docking. Ensemble docking makes use …
sampling molecular dynamics (MD) and ensemble docking. Ensemble docking makes use …
Communication between genomic and non-genomic signaling events coordinate steroid hormone actions
SR Wilkenfeld, C Lin, DE Frigo - Steroids, 2018 - Elsevier
Steroid hormones are lipophilic molecules produced in one cell that can travel great
distances within the body to elicit biological effects in another cell. In the canonical pathway …
distances within the body to elicit biological effects in another cell. In the canonical pathway …
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
AK Lucas-Herald, R Alves-Lopes… - Clinical …, 2017 - portlandpress.com
The principle steroidal androgens are testosterone and its metabolite 5α-
dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α …
dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α …
Membrane androgen receptors unrelated to nuclear steroid receptors
P Thomas - Endocrinology, 2019 - academic.oup.com
Rapid (nongenomic) membrane-initiated androgen actions have been described in nuclear
androgen receptor–null cells. Four distinct proteins have been proposed as membrane …
androgen receptor–null cells. Four distinct proteins have been proposed as membrane …
Sex hormones and lung inflammation
J Reyes-Garcia, LM Montano… - Lung Inflammation in …, 2021 - Springer
Inflammation is a characteristic marker in numerous lung disorders. Several immune cells,
such as macrophages, dendritic cells, eosinophils, as well as T and B lymphocytes …
such as macrophages, dendritic cells, eosinophils, as well as T and B lymphocytes …
Evidence for osteocalcin binding and activation of GPRC6A in β-cells
The possibility that G protein-coupled receptor family C member A (GPRC6A) is the
osteocalcin (Ocn)-sensing G protein-coupled receptor that directly regulates pancreatic β …
osteocalcin (Ocn)-sensing G protein-coupled receptor that directly regulates pancreatic β …
Vascular mechanisms of testosterone: the non-genomic point of view
Testosterone (T) is the predominant endogenous androgen in the bloodstream. At the
vascular level, T presents genomic and non-genomic effects, and both effects may overlap …
vascular level, T presents genomic and non-genomic effects, and both effects may overlap …