The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

The impaired insulin secretion and increased insulin resistance (or decreased insulin
sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is …

Aims/hypothesis The aim of this study was to assess the risk of adverse perinatal outcomes
in gestational diabetes mellitus (GDM) in a large national cohort. Methods All deliveries …

The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue
in human participants. The most frequently used methodologies to evaluate insulin …

Objectives Decreased gut microbial gene richness (MGR) and compositional changes are
associated with adverse metabolism in overweight or moderate obesity, but lack …

OBJECTIVE The objective of this study was to evaluate the effect of maternal hyperglycemia
during pregnancy on cardiometabolic risk in offspring during early childhood. RESEARCH …

Microbiota-host-diet interactions contribute to the development of metabolic diseases.
Imidazole propionate is a novel microbially produced metabolite from histidine, which …

Background Type 1 diabetes results from autoimmune-mediated destruction of β cells. The
tyrosine kinase inhibitor imatinib might affect relevant immunological and metabolic …

Background For patients with obesity and type 2 diabetes, weight loss improves insulin
sensitivity and β-cell function, and can induce remission of diabetes. The comparative …

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders,
affecting 5%-10% of women of reproductive age. The importance of this syndrome lies in the …