Extracellular vesicles (EVs) are nanoscale membrane vesicles released by donor cells that
can be taken up by recipient cells. The study of EVs has the potential to identify unknown …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Endocytic recycling is coordinated with endocytic uptake to control the composition of the
plasma membrane. Although much of our understanding of endocytic recycling has come …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …

Cell migration and spreading involve the coordination of membrane trafficking, actomyosin
contraction, and modifications to plasma membrane tension and area. The biochemical or …

Cell motility is regulated by multiple processes, including cell protrusion, cell retraction, cell–
matrix adhesion, polarized exocytosis and polarized vesicle trafficking, each of which is …

Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

Here we show that blocking the adhesive function of αvβ3 integrin with soluble RGD ligands,
such as osteopontin or cilengitide, promoted association of Rab-coupling protein (RCP) with …