Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …

Abstract Poly (ethylene glycol)(PEG) is a nontoxic, hydrophilic polymer that is often
covalently attached to proteins, drugs, tissues, or materials; a procedure commonly referred …

In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal
anti-poly (ethylene glycol)(anti-PEG) antibody-triggered, complement terminal complex …

PEGylation technique is currently considered the gold standard approach to provide a long
and safe circulation of drugs. Although this is the accepted dogma, various clinical reports …

Pharmacokinetics, biodistribution, and biological activity are key parameters that determine
the success or failure of therapeutics. Many developments intended to improve their in vivo …

Cancer cells display a variety of global metabolic changes, which aside from the glycolytic
pathway largely involve amino acid metabolism. To ensure aggressive growth, tumor cells …

Asparaginase is a critical component of acute lymphoblastic leukemia (ALL) therapy.
Available asparaginase products in the United States include pegaspargase (Oncaspar) …

A total of 548 patients (age range: 1–22 years, 60.4% Hispanic, 55.8% male) diagnosed with
acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity …

Aim: To evaluate the associations between human leukocyte antigen (HLA)-DRB1 variants
and the rs6021191 variant in nuclear factor of activated T cells 2 (NFATC2) with PEG …

Background: Asparaginase poses a substantial risk for hypersensitivity reactions during and
after administration; however, these reactions vary by asparaginase formulation and …