The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …

Sensory experience remodels neural circuits in the early postnatal brain through
mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis …

Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a
spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
involved in many cellular processes, including cell growth and differentiation, immune …

Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe
cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal …

Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory
synaptic transmission and are crucial for many aspects of brain function, including learning …

The high frequency of RAS mutations in human cancers (33%) has stimulated intense
interest in the development of anti-Ras inhibitors for cancer therapy. Currently, the major …

Genome sequencing has revealed an increasing number of genetic variations that are
associated with neuropsychiatric disorders. Frequently, studies limit their focus to likely gene …