Anthropogenic activities pose a more significant threat to the environment than natural
phenomena by contaminating the environment with heavy metals. Cadmium (Cd), a highly …

Copper is a trace element essential for almost all living organisms. But the level of
intracellular copper needs to be tightly regulated. Dysregulation of cellular copper …

P-type ATPases are found in all kingdoms of life and constitute a wide range of cation
transporters, primarily for H+, Na+, K+, Ca2+, and transition metal ions such as Cu (I), Zn (II) …

P-type ATPases constitute a large ancient super-family of primary active pumps that have
diverse substrate specificities ranging from H+ to phospholipids. The significance of these …

In this study a combination of Laser Ablation Inductively Coupled Plasma Mass
Spectrometry (LA-ICP-MS) and Laser Induced Breakdown Spectroscopy (LIBS) was used for …

Zinc is one of the most important metal nutrients for species from all kingdoms, being a key
structural or catalytic component of hundreds of enzymes, crucial for the survival of both …

Cellular potassium import systems play a fundamental role in osmoregulation, pH
homeostasis and membrane potential in all domains of life. In bacteria, the kdp operon …

Copper is essential for living cells, yet toxic at elevated concentrations. Class 1B P-type
(P1B-) ATPases are present in all kingdoms of life, facilitating cellular export of transition …

The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains
copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal …

The human pathogen Mycobacterium tuberculosis requires a P1B-ATPase metal exporter,
CtpC (Rv3270), for resistance to zinc poisoning. Here, we show that zinc resistance also …