Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes,
are at increased risk of developing malignancies, in particular colorectal cancer (CRC) …

The aims of the Prospective Lynch Syndrome Database (PLSD) are to provide empirical
prospectively observed data on the incidences of cancer in different organs, survival …

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …

Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants
of the MMR genes in the PLSD and IMRC cohorts, of which only the former included …

Background Inheritance patterns show familial clustering of gastrointestinal cancers, and
multiple germline conditions have now been identified that predispose to colorectal, gastric …

The recognition of dominantly inherited micro-satellite instable (MSI) cancers caused by
pathogenic variants in one of the four mismatch repair (MMR) genes MSH2, MLH1, MSH6 …

Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-
oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of …

Abstract Purpose of Review Patients with Lynch syndrome have a high probability of
developing colorectal and other carcinomas. This review provides a comprehensive …

See “A 'two-in-one hit'model of shortcut carcinogenesis in MLH1 Lynch syndrome carriers,”
by Ahadova A, Stenzinger A, Seppälä T, et al, on page 267, and “Molecular profile of MSH6 …

Abstract The Prospective Lynch Syndrome Database (PLSD) has been developed as an
international, multicentre, prospective, observational study that aims to provide age and …