Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …

Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Neutrophils are the major circulating white blood cells in humans. They play an essential
role in host defense against pathogens. In healthy individuals, circulating neutrophils are in …

Neutrophils, the most abundant white blood cells in humans, are critical for host defense
against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils …

Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial
and viral products induces neutrophils to transition from a basal state into a primed one …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

Abstract Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an
important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations …

Inflammation is a double-edged sword in the outcome of pneumonia. On the one hand, an
effective and timely inflammatory response is required to eliminate the invading respiratory …

Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …

The production of reactive oxygen species (ROS) within immune cell phagosomes is critical
for antimicrobial activity and for correct antigen processing, and influences signaling …