Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …

Publisher Summary This chapter describes the recent contribution of computer simulation
approaches to unravel the molecular details of membrane fusion. Over the past decade …

Proper lateral dimerization of the transmembrane domains of receptor tyrosine kinases is
required for biochemical signal transduction across the plasma membrane. The spatial …

The human epidermal growth factor receptor (EGFR) of HER/ErbB receptor tyrosine kinase
family mediates a broad spectrum of cellular responses transducing biochemical signals via …

Eph receptors are found in a wide variety of cells in developing and mature tissues and
represent the largest family of receptor tyrosine kinases, regulating cell shape, movements …

Archaeal plasma membranes appear to be extremely durable and almost impermeable to
water and ions, in contrast to the membranes of Bacteria and Eucaryota. Additionally, they …

Hemagglutinin (HA) is a protein located on the surface of the influenza virus that mediates
viral fusion to the host cellular membrane. During the fusion process the HA fusion peptide …

A spin-labeling study of interactions of a fusion peptide from the hemagglutinin of the
influenza virus, wt20, and a fusion-inactive mutant ΔG1 with dimyristoylphosphatidylcholine …

Background Protein membrane transduction domains that are able to cross the plasma
membrane are present in several transcription factors, such as the homeodomain proteins …

The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II
diabetes. One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane …