Advanced strategies to thwart foreign body response to implantable devices

S Capuani, G Malgir, CYX Chua… - Bioengineering & …, 2022 - Wiley Online Library
Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical
for successful long‐term clinical deployment. The FBR is an inevitable immunological …

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

A Grattoni, G Korbutt, AA Tomei, AJ García… - Nature Reviews …, 2024 - nature.com
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration

V Alinezhad, K Esmaeilzadeh, H Bagheri… - Biomaterials …, 2023 - pubs.rsc.org
Wound healing remains a significant challenge worldwide, necessitating the development of
new wound dressings to aid in the healing process. This study presents a novel …

Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing

Y Wang, X Yuan, B Yao, S Zhu, P Zhu, S Huang - Bioactive materials, 2022 - Elsevier
Extrusion-based bioprinting (EBB) holds potential for regenerative medicine. However, the
widely-used bioinks of EBB exhibit some limitations for skin regeneration, such as …

Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) loaded gelatin/silk fibroin hydrogels for improving healing in a murine pressure ulcer model

K Lu, K Li, M Zhang, Z Fang, P Wu, L Feng… - Chemical Engineering …, 2021 - Elsevier
Pressure ulcers are areas of localized damage to the skin and underlying tissue, which
impose a major burden to patients and medical systems. Natural polymeric hydrogels …

[HTML][HTML] Emerging immunomodulatory strategies for cell therapeutics

CYX Chua, AY Jiang, T Eufrásio-da-Silva… - Trends in …, 2023 - cell.com
Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …

Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

J Paez-Mayorga, JN Campa-Carranza… - Nature …, 2022 - nature.com
Pancreatic islet transplantation efficacy for type 1 diabetes (T1D) management is limited by
hypoxia-related graft attrition and need for systemic immunosuppression. To overcome …

Nematic fibrin fibers enabling vascularized thrombus implants facilitate scarless cutaneous wound healing

SH Jung, BH Jang, S Kwon, SJ Park… - Advanced …, 2023 - Wiley Online Library
Autologous implantable scaffolds that induce vasculogenesis have shown great potential in
tissue regeneration; however, previous attempts mainly relied on cell‐laden hydrogel …

3D printed scaffolds incorporated with platelet‐rich plasma show enhanced angiogenic potential while not inducing fibrosis

RIR Ibanez, RJFC do Amaral… - Advanced Functional …, 2022 - Wiley Online Library
Successful therapeutic strategies for wound healing rely on proper vascularization while
inhibiting fibrosis. However, scaffolds designed for skin tissue engineering generally lack the …

Emerging strategies for beta cell transplantation to treat diabetes

J Paez-Mayorga, I Lukin, D Emerich, P de Vos… - Trends in …, 2022 - cell.com
Beta cell replacement has emerged as an attractive therapeutic alternative to traditional
exogenous insulin administration for management of type 1 diabetes (T1D). Beta cells …