Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

[HTML][HTML] Antimicrobial peptides: new hope in the war against multidrug resistance

J Mwangi, X Hao, R Lai, ZY Zhang - Zoological research, 2019 - ncbi.nlm.nih.gov
The discovery of antibiotics marked a golden age in the revolution of human medicine.
However, decades later, bacterial infections remain a global healthcare threat, and a return …

Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria

JM Ageitos, A Sánchez-Pérez, P Calo-Mata… - Biochemical …, 2017 - Elsevier
Antimicrobial peptides (AMPs) are short peptidic molecules produced by most living
creatures. They help unicellular organisms to successfully compete for nutrients with other …

[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides

DI Andersson, D Hughes… - Drug Resistance Updates, 2016 - Elsevier
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

Chemistry and enzymology of disulfide cross-linking in proteins

D Fass, C Thorpe - Chemical reviews, 2018 - ACS Publications
Cysteine thiols are among the most reactive functional groups in proteins, and their pairing
in disulfide linkages is a common post-translational modification in proteins entering the …

Antimicrobial peptides: An overview of their structure, function and mechanism of action

R Zhang, L Xu, C Dong - Protein and Peptide Letters, 2022 - ingentaconnect.com
In recent years, the antibiotic resistance of pathogenic bacteria has become an increasing
public health threat. Finding alternatives to antibiotics may be an effective solution to the …

Physicochemical Features and Peculiarities of Interaction of AMP with the Membrane

M Pirtskhalava, B Vishnepolsky, M Grigolava… - Pharmaceuticals, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are anti-infectives that have the potential to be used as a
novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides …

[HTML][HTML] A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis

IG Sérézal, E Hoffer, B Ignatov, E Martini, B Zitti… - Journal of Allergy and …, 2019 - Elsevier
Background Resident T cells are implicated in the maintenance and recurrence of psoriatic
lesions. Whether skin that has not yet experienced psoriasis in patients with established …

The dual interaction of antimicrobial peptides on bacteria and cancer cells; mechanism of action and therapeutic strategies of nanostructures

A Parchebafi, F Tamanaee, H Ehteram, E Ahmad… - Microbial Cell …, 2022 - Springer
Microbial infection and cancer are two leading causes of global mortality. Discovering and
developing new therapeutics with better specificity having minimal side-effects and no drug …