The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor
for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent …

Background: Chronic diseases such as diabetes have an adverse effect on the quality of life
(QOL) of patients. It has been shown physical activity can improve the quality of life. Aims …

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

Leptin, an adipokine that is implicated in the control of food intake via appetite suppression,
may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness …

Background Although there is substantial evidence of differential hypothalamic-pituitary-
adrenal (HPA) axis activity in both generalized and abdominal obesity, consistent trends in …

Metabolic syndrome (MetS), today a major global public health problem, is a cluster of
clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension …

Although discussion of the obesity epidemic had become a cocktail party cliché, its impact
on public health cannot be dismissed. In the past decade, cancer had joined the list of …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …