A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …

The rule of 5 (Ro5) is a set of in silico guidelines applied to drug discovery to prioritize
compounds with an increased likelihood of high oral absorption. It has been influential in …

Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …

Drug discovery for difficult targets that have large and flat binding sites is often better suited
to compounds beyond the “rule of 5”(bRo5). However, such compounds carry higher …

Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …

Drug discovery and development is a complex and lengthy enterprise that suffers from high
rates of candidate attrition at all stages of the process. The physical, biological, and …

Physicochemical properties underlie all aspects of drug action and are critical for solubility,
permeability and successful formulation. Specific physicochemical properties shown to be …

Introduction: Pharmacokinetics involves the study of absorption, distribution, metabolism,
excretion and toxicity of xenobiotics (ADME-Tox). In this sense, the ADME-Tox profile of a …

The rule of 5 was designed to estimate the likelihood of poor absorption or permeation,
noting the impact of poor solubility. This Perspective explores the impact of various …

Syntheses and characterizations of the arene ruthenium [(η6-C6H6) RuCl (4-mtdpm)](1),[(η6-
p-MeC6H4Pri) RuCl (4-mtdpm)](2), and structurally analogous rhodium/iridium complexes …