Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important
human pathogen that causes considerable morbidity and mortality worldwide. The GAS …

Most invasive bacterial infections are caused by species that more commonly colonize the
human host with minimal symptoms. Although phenotypic or genetic correlates underlying a …

In order for invasive pathogens to migrate beyond the site of infection, host physiological
barriers such as the extracellular matrix, the basement membrane, and encapsulating fibrin …

Autophagy is reported to be an important innate immune defense against the intracellular
bacterial pathogen Group A Streptococcus (GAS). However, the GAS strains examined to …

There is mounting evidence that the hemostatic system is critical in host responses to
bacterial infection. Invasive bacteria have evolved virulence strategies to interact with host …

The globally disseminated Streptococcus pyogenes M1T1 clone causes a number of highly
invasive human diseases. The transition from local to systemic infection occurs by an …

Necrotizing fasciitis, also known as the flesh-eating disease, is a severe invasive infection
associated with very high rates of human morbidity and mortality. It is most commonly …

Multiple species of bacteria are able to sequester the host zymogen plasminogen to the cell
surface. Once localised to the bacterial surface, plasminogen can act as a cofactor in …

Group A Streptococcus (GAS) has long been recognized as a human pathogen causing an
exceptionally broad range of infections. Despite intense research, however, the molecular …