Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous skeletal
dysplasia characterized by bone fragility, growth deficiency, and skeletal deformity …

Understanding the detailed mechanism behind every human disease, disorder, defect, and
deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

The identification of disease-causing mutations has in recent years progressed immensely
due to whole genome sequencing approaches using patient material. The task accordingly …

Immobilization as a result of long‐term bed rest can lead to gradual bone loss. Because of
their distribution throughout the bone matrix and remarkable interconnectivity, osteocytes …

Bone continuously adapts to its mechanical environment by structural reorganization to
maintain mechanical strength. As the adaptive capabilities of bone are portrayed in its nano …

Advances in next‐generation sequencing have transformed our ability to identify genetic
variants associated with clinical disorders of the musculoskeletal system. However, the …