C/EBP homologous protein (CHOP), known also as DNA damage-inducible transcript 3 and
as growth arrest and DNA damage-inducible protein 153 (GADD153), is induced in …

Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-
aged people and elderly people, and the pathogenesis of PD is complex and diverse. The …

Mounting evidence from clinical, epidemiological, neuropathology and preclinical studies
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …

Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many
diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of …

Endoplasmic reticulum (ER) proteins including protein disulfide isomerase (PDI) are playing
crucial roles in maintaining appropriate protein folding. Under nitrosative stress, an excess …

Cells regularly synthesize new proteins to replace old and abnormal proteins for normal
cellular functions. Two significant protein quality control pathways inside the cellular milieu …

There are three members of the endogenous gas transmitter family. The first two are nitric
oxide and carbon monoxide, and the third newly added member is hydrogen sulfide (H2S) …

Brain ischemia is a major cause of adult disability and death, and it represents a worldwide
health problem with significant economic burden for modern society. The identification of the …

Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5′-triphosphorylated RNA and
triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent …

The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis,
and dopaminergic neurodegeneration. We conducted a further mechanistic investigation …