The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Despite the development of effective therapies, a substantial proportion of asthmatics
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

Introduction TRPA1 is a non-selective cation channel predominantly expressed in sensory
neurons, and functions as an irritant sensor for a plethora of noxious external stimuli and …

TRPA1 is a cation channel located on the plasma membrane of many types of human and
animal cells, including skin sensory neurons and epithelial cells of the intestine, lungs …

The lungs are essential for gas exchange and serve as the gateways of our body to the
external environment. They are easily accessible for drugs from both sides, the airways and …

Background Apical periodontitis (AP) is an inflammatory disease affecting periradicular
tissues. It is a widespread condition but its etiopathogenetic mechanisms have not been …

Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion
channel, and activation thereof is linked to a variety of painful conditions. Preclinical studies …

The transient receptor potential ankyrin 1 (TRPA1) channel is an irritant sensor highly
expressed on nociceptive neurons. The clinical use of TRPA1 antagonists is based on the …