Patients with heart failure with preserved ejection fraction (HFpEF) universally complain of
exercise intolerance and dyspnoea as key clinical correlates. Cardiac as well as …

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a role in post-
transcriptional gene regulation. It is generally accepted that their main mechanism of action …

Recent advances in technology such as the introduction of high throughput
multidimensional tools like single cell sequencing help to characterize the cellular …

Importance Reduced heart rate during exercise is common and associated with impaired
aerobic capacity in heart failure with preserved ejection fraction (HFpEF), but it remains …

Heart failure with preserved ejection fraction (HFpEF) is defined by increased left ventricular
(LV) stiffness, impaired vascular compliance, and fibrosis. Although systemic inflammation …

Background Heart failure (HF) with preserved ejection fraction (HFpEF) prevalence is
increasing, and large clinical trials have failed to reduce mortality. A major reason for this …

Aims In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an
important predictor of mortality, yet its molecular underpinnings are poorly understood …

Background Atrial fibrillation (AF) is a common comorbidity in heart failure with preserved
ejection fraction (HFpEF) patients. To date, treatments for HFpEF-related AF have been …

Background Exercise‐induced high heart rate may impair exercise tolerance by reducing
diastolic filling time and ventricular filling in heart failure with preserved ejection fraction …

Aims The sympathetic nervous system increases HR by activating β-adrenergic receptors (β-
ARs) and increasing cAMP in sinoatrial node (SAN) myocytes while phosphodiesterases …