The sentinel role of the airway epithelium in asthma pathogenesis

ST Holgate - Immunological reviews, 2011 - Wiley Online Library
The adoption of the concept that asthma is primarily a disease most frequently associated
with elaboration of T‐helper 2 (Th2)‐type inflammation has led to the widely held concept …

Detection of respiratory viruses by molecular methods

JB Mahony - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Clinical laboratories historically diagnose seven or eight respiratory virus infections using a
combination of techniques including enzyme immunoassay, direct fluorescent antibody …

[HTML][HTML] Why does viral RNA sometimes persist after recovery from acute infections?

DE Griffin - PLoS biology, 2022 - journals.plos.org
DNA viruses often persist in the body of their host, becoming latent and recurring many
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …

Epithelium dysfunction in asthma

ST Holgate - Journal of Allergy and Clinical Immunology, 2007 - Elsevier
Although asthma is an inflammatory disorder of the conducting airways involving TH2-type T
cells, there is increasing evidence for an important role played by the epithelium in …

Viruses and bacteria in acute asthma exacerbations – A GA2LEN‐DARE* systematic review

NG Papadopoulos, I Christodoulou, G Rohde… - Allergy, 2011 - Wiley Online Library
To cite this article: Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C,
Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, Braido F, Brusselle G, Canonica GW …

Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children

MK Iwane, MM Prill, X Lu, EK Miller… - Journal of Infectious …, 2011 - academic.oup.com
Background. The contribution of human rhinovirus (HRV) to severe acute respiratory illness
(ARI) is unclear. Objective. To assess the association between HRV species detection and …

Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses

X Lu, B Holloway, RK Dare, J Kuypers… - Journal of clinical …, 2008 - Am Soc Microbiol
Human rhinoviruses (HRVs) are important contributors to respiratory disease, but their
healthcare burden remains unclear, primarily because of the lack of sensitive, accurate, and …

Identification of respiratory viruses in asymptomatic subjects: asymptomatic respiratory viral infections

T Jartti, L Jartti, V Peltola, M Waris… - The Pediatric infectious …, 2008 - journals.lww.com
The medical literature of the past 4 decades was searched regarding respiratory virus
detection by polymerase chain reaction and conventional methods (culture, antigen …

Pathogenesis of rhinovirus infection

JL Kennedy, RB Turner, T Braciale… - Current opinion in …, 2012 - Elsevier
Since its discovery in 1956, rhinovirus (RV) has been recognized as the most important virus
producing the common cold syndrome. Despite its ubiquity, little is known concerning the …

Epidemiology of asthma exacerbations

MR Sears - Journal of Allergy and Clinical Immunology, 2008 - Elsevier
Exacerbations of asthma sufficient to require urgent medical intervention are often, but not
always, associated with viral infection, especially rhinovirus, with significant interaction with …