The protein-protein docking problem is one of the focal points of activity in computational
biophysics and structural biology. The three-dimensional structure of a protein-protein …

Highlights•Search strategies of current protein–protein docking algorithms were
reviewed.•Challenges and future directions of established approaches were discussed.•Post …

The prediction of the quaternary structure of biomolecular macromolecules is of paramount
importance for fundamental understanding of cellular processes and drug design. In the era …

Protein–protein interactions are fundamental to many biological processes. Experimental
screens have identified tens of thousands of interactions, and structural biology has …

Back and forth transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) between humans and animals will establish wild reservoirs of virus that endanger long …

B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using
receptors secreted or expressed on their surface (antibodies). This is achieved via molecular …

Protein–protein docking is an important computational tool for predicting protein–protein
interactions. With the rapid development of proteomics projects, more and more …

Emergence of new viral agents is driven by evolution of interactions between viral proteins
and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV …

With the success of an expanding array of genome sequencing projects, the number of
known protein sequences has been increasing exponentially. However, the sequences on …

In CASP14, 39 research groups submitted more than 2500 3D models on 22 protein
complexes. In general, the community performed well in predicting the fold of the assemblies …