Abstract Glycogen phosphorylase (GP)(EC 2.4. 1.1) is an important therapeutic target for the
potential treatment of type 2 diabetes. The search for potent, selective and drug-like GP …

The huge increase in type 2 diabetes is a burden worldwide. Many marketed compounds do
not address relevant aspects of the disease; they may already compensate for defects in …

Glycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context
of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into …

Glucose-phosphorylating enzyme, glucokinase (GK) plays a major role in glucose
homeostasis primarily through its regulatory actions in pancreatic β-cells and liver …

Glucokinase is a key enzyme which converts glucose into glucose‐6‐phosphate in the liver
and pancreatic cells of the human. In the liver, glucokinase promotes the synthesis of …

The significant role played by docking algorithms in drug discovery combined with their
serious pitfalls prompted us to envisage a novel concept for validating docking solutions …

Four series of novel pyrazole derivatives (compounds 17a–m, 18a–m, 19a–g, and 20a–g)
were synthesized, and their antibacterial and antifungal activities were evaluated. Most of …

Background: Glucokinase (GK), a cytoplasmic enzyme catalyzes the metabolism of glucose
to glucose-6-phosphate with the help of ATP and aids in the controlling of blood glucose …

Abstract Six series of 4-(benzo [c][1, 2, 5] thiadiazol-5-yl)-3 (5)-(6-methylpyridin-2-yl)-
pyrazoles 18a–d, 19a–d, 22a–d and 3 (5)-(6-methylpyridin-2-yl)-4-(thieno [3, 2,-c]-pyridin-2 …

Edible fungi polysaccharides are widely sourced and have various physiological activities,
including hypoglycemic. Current studies mainly focus on the hypoglycemic activity of …