Brain energy metabolism: astrocytes in neurodegenerative diseases

Z Chen, Z Yuan, S Yang, Y Zhu, M Xue… - CNS neuroscience & …, 2023 - Wiley Online Library
Astrocytes are the most abundant cells in the brain. They have many important functions in
the central nervous system (CNS), including the maintenance of glutamate and ion …

SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells

C Peggion, V Scalcon, ML Massimino, K Nies… - Antioxidants, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …

Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration

A Labarre, E Guitard, G Tossing, A Forest… - Communications …, 2022 - nature.com
The human microbiota is believed to influence health. Microbiome dysbiosis may be linked
to neurological conditions like Alzheimer's disease, amyotrophic lateral sclerosis, and …

Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia

CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity

W Ng, SY Ng - Translational neurodegeneration, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …

The need for biomarkers in the ALS–FTD spectrum: a clinical point of view on the role of proteomics

F Vignaroli, A Mele, G Tondo, V De Giorgis, M Manfredi… - Proteomes, 2023 - mdpi.com
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are severely
debilitating and progressive neurodegenerative disorders. A distinctive pathological feature …

Current Insights on Neurodegeneration by the Italian Proteomics Community

T Alberio, M Brughera, M Lualdi - Biomedicines, 2022 - mdpi.com
The growing number of patients affected by neurodegenerative disorders represents a huge
problem for healthcare systems, human society, and economics. In this context, omics …

Secreted Metabolome of ALS-Related hSOD1 (G93A) Primary Cultures of Myocytes and Implications for Myogenesis

R Stella, RS Bonadio, S Cagnin, R Andreotti… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease associated with
progressive muscle atrophy, paralysis, and eventually death. Growing evidence …

Acacia catechu Willd. Extract Protects Neuronal Cells from Oxidative Stress-Induced Damage

E Chiaino, R Stella, C Peggion, M Micucci, R Budriesi… - Antioxidants, 2021 - mdpi.com
Oxidative stress (OS) and the resulting reactive oxygen species (ROS) generation and
inflammation play a pivotal role in the neuronal loss occurring during the onset of …

From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis.

L Castelli, R Vasta, SP Allen, R Waller… - International Review …, 2024 - europepmc.org
Amyotrophic lateral sclerosis (ALS) is a heterogeneous progressive neurodegenerative
disorder with available treatments such as riluzole and edaravone extending survival by an …