Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

Nuclear magnetic resonance (NMR) spectroscopy is a wide-spread analytical technique
which is used in a large range of different fields, such as quality control, food analysis …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful high-resolution tool for
characterizing biomacromolecular structure, dynamics, and interactions. However, the …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

With the development of NMR methodology and technology during the past decades, solid-
state NMR (ssNMR) has become a particularly important tool for investigating structure and …

Nuclear spin hyperpolarization provides a promising route to overcome the challenges
imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that …

Abstract Nuclear Magnetic Resonance (NMR) spectroscopy is a most powerful molecular
characterization and quantification technique, yet two major persistent factors limit its more …

Most experimental methods for structural biology proceed in vitro and therefore the
contribution of the intracellular environment on protein structure and dynamics is absent …