Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral
haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the …

There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess
cerebrovascular function. The brain is unique in its high energy and oxygen demand but …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

Introduction Postoperative delirium is common in older patients. Despite its prognostic
significance, the pathophysiology is incompletely understood. Although many risk factors …

As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …

Functional magnetic resonance imaging (fMRI) is a non-invasive technique that allows for
visualization of activated brain regions. Until recently, fMRI studies have focused on gray …

This review article explains the methodology of breath-hold cerebrovascular reactivity
mapping, both in terms of acquisition and analysis, and reviews applications of this method …