Parkinson's disease (PD) is a neurodegenerative disorder caused by the depletion of
dopaminergic neurons in the basal ganglia, the movement center of the brain …

The accumulation of protein aggregates in human tissues is a hallmark of more than 40
diseases called amyloidoses. In seven of these disorders, the aggregation is associated with …

The aggregation of α‐synuclein plays a pivotal role in the pathogenesis of Parkinson's
disease (PD). Epidemiological evidence indicates that high level of homocysteine (Hcy) is …

Abstract α-Synuclein is an intrinsically disordered protein that can self-aggregate and plays
a major role in Parkinson's disease (PD). Elevated levels of certain metal ions are found in …

Amyloid fibrils, insoluble β‐sheets structures that arise from protein misfolding, are
associated with several neurodegenerative disorders. Many small molecules have been …

Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative
disorders of the elderly and, therefore, affect a growing number of patients worldwide. Both …

Ion mobility mass spectrometry (IM-MS) has proven to be an excellent method to
characterize the structure of amyloidogenic protein and peptide aggregates, which are …

Significance: The systematic investigation of oxidative modification of proteins by reactive
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …

Parkinson's disease, a neurodegenerative disease that affects 15 million people worldwide,
is characterized by deposition of α-synuclein into Lewy Bodies in brain neurons. Although …

Oligomers of the protein α-synuclein (α-syn) are thought to be a major toxic species in
Parkinson's disease, particularly through their ability to permeabilize cell membranes. The …