Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …

Achieving selective C− H activation at a single and strategic site in the presence of multiple
C− H bonds can provide a powerful and generally useful retrosynthetic disconnection. In this …

The transition metal-catalyzed transformation of otherwise inert C–H bonds into substituted
alkenes offers a versatile tool for the synthesis of value added olefinic molecules. Recent …

The development of new strategies and chemical reactions continues to be a major focus of
research efforts in the modern synthetic organic community. 1 Of the various types of …

An efficient Rh (III)-and Ir (III)-catalyzed, chelation-assisted C–H alkynylation of a broad
scope of (hetero) arenes has been developed using hypervalent iodine-alkyne reagents …

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a
classical strategy in medicinal chemistry. The general underlying principle is that by …

Recently, carbonylation reactions have gained considerable interest as they are becoming a
versatile tool in the synthesis of pharmaceuticals, agrochemicals and their intermediates …

The metal-catalyzed “cascade C–H activation/annulation” is a highly promising approach to
the construction of aromatic and heteroaromatic compounds. In this context, Pd-complexes …

An enantioselective method for Pd (II)-catalyzed cross-coupling of methylene β-C (sp3)–H
bonds in cyclobutanecarboxylic acid derivatives with arylboron reagents is described. High …

Esters are valuable commodity chemicals widely found in agrochemicals, pharmaceuticals,
and advanced materials. They are also important synthetic building blocks for chemical …