The neuroprotective role of melatonin in neurological disorders

BS Alghamdi - Journal of neuroscience research, 2018 - Wiley Online Library
Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Melatonin: A potential nighttime guardian against Alzheimer's

Z Zhang, P Xue, BB Bendlin, H Zetterberg… - Molecular …, 2024 - nature.com
In the context of the escalating global health challenge posed by Alzheimer's disease (AD),
this comprehensive review considers the potential of melatonin in both preventive and …

Biology of microglia in the developing brain

C Kaur, G Rathnasamy, EA Ling - Journal of Neuropathology & …, 2017 - academic.oup.com
Microglia exist in different morphological forms in the developing brain. They show a small
cell body with scanty cytoplasm with many branching processes in the grey matter of the …

Pineal gland tumors: a review

G Favero, F Bonomini, R Rezzani - Cancers, 2021 - mdpi.com
Simple Summary Pineal neoplasms are tumors with different and variable morphological,
histological, and radiological characteristics and, consequently different diagnosis and …

Ischemic brain injury: New insights on the protective role of melatonin

E Ramos, P Patiño, RJ Reiter, E Gil-Martín… - Free Radical Biology …, 2017 - Elsevier
Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …

Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling …

S Zhang, P Wang, L Ren, C Hu, J Bi - Alzheimer's research & therapy, 2016 - Springer
Background Amyloid-beta (Aβ) plays a key role in Alzheimer's disease (AD) pathogenesis,
and soluble Aβ oligomers are more cytotoxic than Aβ fibrils. Recent evidence suggests that …

[PDF][PDF] Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier

R Mineiro, MR Cardoso, AC Duarte… - Front …, 2024 - researchgate.net
The blood–brain barrier and the blood-cerebrospinal fluid barrier separate the blood from
brain tissue and cerebrospinal fluid. These brain barriers are important to maintain …

Melatonin pharmacokinetics following oral administration in preterm neonates

S Carloni, F Proietti, M Rocchi, M Longini, L Marseglia… - Molecules, 2017 - mdpi.com
Melatonin possesses potential efficacy in perinatal brain injuries, and has been proposed as
adjunctive pharmacological therapy in combination with hypothermia in the clinical setting …

Variations in melatonin levels in preterm and term human breast milk during the first month after delivery

Y Qin, W Shi, J Zhuang, Y Liu, L Tang, J Bu, J Sun… - Scientific reports, 2019 - nature.com
The objectives of the present study were to examine the dynamic changes in breast milk
melatonin throughout the course of lactation and to explore factors associated with changes …

[HTML][HTML] Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/NF-κB signaling pathway after LPS treatment in neonatal rats

Y Hu, Z Wang, S Pan, H Zhang, M Fang, H Jiang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hypoxic-ischemic and inflammatory (HII) induces the disruption of blood–brain barrier (BBB)
which leads to inflammatory responses and neuronal cell death, resulting in brain secondary …